MDC proteins and DNAs encoding the same
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United States of America Patent
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Jan 6, 1998
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app pub date -
Jun 7, 1995
filing date -
May 14, 1993
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Abstract
The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ('MDC protein') encoded by the gene and a method for the diagnosis of cancer by using an antibody combinable to the protein. A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as an antigen.
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