2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
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United States of America Patent
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Dec 23, 1997
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N/A
app pub date -
Nov 22, 1995
filing date -
Nov 29, 1994
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Expired
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Abstract
Unique benzothiazole derivatives which exert superior aldose redactase inhibiting actions are unexpectedly and advantageously useful in the prophylactic and therapeutic treatment of diabetic complications. A benzothiazole derivative compound of the formula (1): ##STR1## wherein X is halogen, R.sup.1 and R.sup.2, which are the same or different, are each independently hydrogen or halogen, A is a methylene group or a sulfur atom, and --B--COOR.sup.3 is a group as defined in the specification; or a pharmaceutically acceptable salt and a pharmaceutical composition comprising the same which is a useful prophylactic or therapeutic agent for the treatment of diabetic complications.
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