HIV-1 gag cytotoxic T-lymphocyte epitope and method of use
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United States of America Patent
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Dec 23, 1997
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N/A
app pub date -
Dec 19, 1994
filing date -
Aug 9, 1989
priority date (Note) -
Expired
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Abstract
A novel human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte (CTL) epitope has been identified in the gag coding region. This epitope corresponds to amino acids 255-269 of Gag and has the following sequence: NH.sub.2 -asn-pro-pro-ile-pro-val-gly-glu-ile-tyr-lys-arg-trp-ile-ile-COOH. This peptide interacts specifically with human leukocyte antigen-B8 (HLA-B8). This peptide is useful for the identification HIV-1 gag-specific CTL.
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