Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
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United States of America Patent
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Dec 9, 1997
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N/A
app pub date -
Jun 2, 1995
filing date -
Aug 23, 1991
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Abstract
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.
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