Process for the manufacture of 3-amino-substituted glycosylated bile acids

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United States of America Patent

PATENT NO 5693770
SERIAL NO

08494194

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Abstract

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The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.

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Patent OwnerAddress
INTERCARDIA INCP O BOX 14287 RESEARCH TRIANGLE NC 27709

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Anna K Rahway, NJ 3 0
Kakarla, Ramesh East Brunswick, NJ 25 217
Liu, Dashan East Brunswick, NJ 6 17
Sofia, Michael J Lawrenceville, NJ 34 288
Zebovitz, Thomas C Colonia, NJ 3 0

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