Method of isolating .beta.A4 peptide species ending at carboxy-terminals residue 42 using monoclonal antibody 369.2B
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United States of America Patent
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Dec 2, 1997
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N/A
app pub date -
Jun 7, 1995
filing date -
Feb 14, 1995
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Abstract
The instant invention provides for monoclonal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 '1-42' but not '1-43', and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
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