DNA encoding lipase from human gastric mucosal tissue

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United States of America Patent

PATENT NO 5691181
SERIAL NO

08340123

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Abstract

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A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric lipase or precursor of the gastric lipase which may be cleaved to yield the gastric lipase. The host organism is transformed with a vector including a gene coding for a methionine-gastric lipase or a precursor of gastric lipase. The precursor protein is for example, pregastric lipase protein, or a fusion protein comprising gastric lipase and a heterologous protein. A pharmaceutical composition in unit dosage or liquid form is described.

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Patent Owner(s)

Patent OwnerAddress
CELLTECH LIMITED216 BATH ROAD SLOUGH SL1 4EN BERKSHIRE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lowe, Peter Anthony Reading, GB 2 52

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