Methods and compositions for inhibiting thrombogenesis
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United States of America Patent
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-
Nov 18, 1997
Grant Date -
N/A
app pub date -
Nov 13, 1995
filing date -
Dec 27, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Thrombus or clot formation and accretion are inhibited by administering thrombin-displacing substances to a patient. The thrombin-displacing substances comprise either thrombin analogs which bind to the thrombin-binding site on fibrin or fibrin analogs which bind to a fibrin-binding site on thrombin. By displacing the thrombin from clot or thrombus, the thrombin is released into circulation where it is inactivated by endogenous anti-proteinases. The fibrin analogs which bind to the fibrin-binding site on thrombin may be linked to a second binding moiety which binds to and/or inactivates the catalytic site on thrombin to further inhibit thrombosis.
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