Antagonism of endothelin actions
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United States of America Patent
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Nov 18, 1997
Grant Date -
N/A
app pub date -
Mar 13, 1996
filing date -
Mar 13, 1996
priority date (Note) -
Expired
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Abstract
The mechanism of hypertension following acute NO synthase blockade is via endothelin mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a `normal` physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.
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