Methionine sulfone and s-substituted cysteine sulfone derivatives as enzyme inhibitors
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United States of America Patent
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Oct 28, 1997
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app pub date -
Apr 28, 1994
filing date -
Apr 18, 1994
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Abstract
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
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