Methods for producing enhanced antigenic shigella bacteria and vaccines comprising same
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United States of America Patent
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Oct 28, 1997
Grant Date -
N/A
app pub date -
Oct 3, 1995
filing date -
Oct 5, 1994
priority date (Note) -
Expired
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Abstract
Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced enteric bacteria. Also methods for using the antigenically enhanced bacteria are also disclosed, as well as vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof are provided by Shigella species. Also there are other enteric bacteria which are useful for the disclosed invention; such as bacterial species and strains belonging to the genera Helicobacter and Campylobacter.
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