Synthetic peptide compositions with immunoreactivities to antibodies to HTLV
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United States of America Patent
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Oct 28, 1997
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N/A
app pub date -
Jun 1, 1995
filing date -
Jan 9, 1987
priority date (Note) -
Expired
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Abstract
The present invention relates to a method for the detection HTLV-I and/or HTLV-II reactive antibodies and diagnosis of ATL (adult T cell leukemia/lymphoma) condition by the use of chemically synthesized peptide compositions. The peptide compositions comprise peptides having amino acid sequences corresponding to transmembrane and external segments of the envelope protein of HTLV-I/HTLV-II and mixtures thereof. The peptide compositions are highly immunoreactive with antibodies to HTLV in sera. The present invention further relates to a method for the simultaneous detection and diagnosis of ATL, HTLV-I and/or HTLV-II infection and Acquired Immune Deficiency Syndrome (AIDS) by the use of chemically synthesized HTLV peptide compositions in conjunction with a chemically synthesized HIV (1 and 2) peptide composition. The present invention also provides a simple method to differentiate between HTLV-I and HTLV-II infections. The detection method includes an enzyme-linked immunosorbent assay (ELISA), an immunoradiometric assay (IRMA), and other forms of immunoassay procedures such as enzyme immuno blotting assay on nitrocellulose paper and an agglutination assay using the peptide composition as the antigen. The preferred detection method is ELISA.
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