Thiadiazole compounds useful as proton pump inhibitors
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United States of America Patent
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Oct 14, 1997
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N/A
app pub date -
Feb 26, 1996
filing date -
Feb 26, 1996
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Abstract
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H.sup.+ /K.sup.+ -ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo ?4,5-.alpha.!benzimidazole and 3-substituted imidazo?1,2-d!-1,2,4-thiadiazoles corresponding to the general formula: ##STR1## where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is an electronegative group.
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