Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
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United States of America Patent
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Sep 23, 1997
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N/A
app pub date -
Jan 4, 1996
filing date -
Aug 5, 1994
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Expired
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Abstract
Certain triphenylpiperidines reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
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