3-amido-triiodophenyl esters as x-ray contrast agents

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United States of America Patent

PATENT NO 5668196
SERIAL NO

08677709

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Abstract

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This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 0 to 12 m is 1 or 2 ##STR2## R.sup.1 is X and Z are independently H or NR.sup.2 COR.sup.3 Y is CO.sub.2, CH.sub.2 O, O or NH and R.sup.2 and R.sup.3 are independently H, alkyl having from 1 to 12 carbon atoms or aryl having from 6 to 11 carbon atoms, This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is ##STR3## R.sup.2 is H and R.sup.3 is CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.

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Patent Owner(s)

Patent OwnerAddress
ALKERMES PHARMA IRELAND LIMITED1 BURLINGTON ROAD CONNAUGHT HOUSE DUBLIN D04 C5Y6

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bacon, Edward R Audubon, PA 64 806
Josef, Kurt A Wayne, PA 27 173
Robinson, Shaugnessy Westerly, RI 1 10

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