Aromatic heterocyclic derivatives as enzyme inhibitors
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United States of America Patent
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Aug 12, 1997
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Jun 7, 1995
filing date -
Dec 13, 1994
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Abstract
The present invention discloses heterocyclic aromatic peptide aldehydes which have an oxopyrimidine or oxopyridine group and an argininal tail which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
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