Process for the preparation of cyclosporin a from tolypocladium species
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United States of America Patent
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Aug 12, 1997
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N/A
app pub date -
Jun 16, 1995
filing date -
Feb 1, 1995
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Expired
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Abstract
The invention relates to a process for the preparation of cyclosporin A from Tolypocladium Sp comprising in the step of preparing a fermented medium of said Tolypocladium sp. The fungal biomass is extracted of said fermented medium to obtain a methanol extract, which methanol is removed by evaporation to obtain a first residue. An ethyl acetate extract is prepared from the aqueous solution of said first residue, which is decolourized and concentrated to obtain a second residue, the second residue is subjected to a step of purification.
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