Peptide plasminogen activators
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United States of America Patent
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Aug 12, 1997
Issued Date -
N/A
app pub date -
Jan 31, 1995
filing date -
Dec 23, 1985
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Abstract
Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.
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