Ligands useful in radiographic imaging

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United States of America Patent

PATENT NO 5656253
SERIAL NO

08255148

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Abstract

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The present invention relates particularly to novel pyridine based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes, novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes, and amide-thiolate ligands having improved metal chelate formation kinetics. The amide-thiolate ligands include an amine which converts to a vinylogous amide upon complexation, thereby providing rapid complexation and thermodynamic stability. The ligands may be used for post formed labeling of biological substances for use in the fields of diagnosis and therapy.

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Patent Owner(s)

Patent OwnerAddress
MALLINCKRODT MEDICAL INCA CORP OF DE ST LOUIS MO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rajagopalan, Raghavan Maryland Heights, MO 162 2269
Srinivasan, Ananthachari St. Charles, MO 50 1281
Vanderheyden, Jean-Luc St. Louis, MO 10 251

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