Macrophage migration inhibitory factor-3
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United States of America Patent
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Jul 22, 1997
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N/A
app pub date -
Jun 2, 1995
filing date -
Jun 2, 1995
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Abstract
The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases. Also disclosed are diagnostic methods for detecting conditions related to a mutation in a nucleic acid sequence encoding a polypeptide of the present invention and altered levels of the polypeptide of the present invention.
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