Diarylalkyl piperidines useful as multi-drug resistant tumor agents
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United States of America Patent
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Jul 15, 1997
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Mar 11, 1996
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Jan 21, 1993
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Abstract
Diarylalkyl piperidines of formula (1) ##STR1## reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
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