Bone targeted inhibitors of carbonic anhydrase
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United States of America Patent
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Jun 24, 1997
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app pub date -
Jul 1, 1994
filing date -
May 2, 1985
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Abstract
The present invention relates to novel compounds useful for the treatment and prophylaxis of degenerative bone disorders and to the preparation thereof. These compounds are particularly characterized by two active moieties, the first of which possesses 'bone-seeking' affinity and the second which is an inhibition of the enzyme carbonic anhydrase and/or an inhibitor of bone resorption. The novel compounds of this invention can be administered as pharmaceutically acceptable compositions and in convenient dosage unit form in a method for the treatment and prophylaxis of degenerative bone disorders.
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