Irradiated tumor cell vaccine engineered to express GM-CSF
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United States of America Patent
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Jun 10, 1997
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app pub date -
Jun 23, 1994
filing date -
Oct 4, 1991
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Abstract
A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.
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