Cytotoxic enhancement of TNF with copper
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United States of America Patent
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May 27, 1997
Grant Date -
N/A
app pub date -
Jun 7, 1994
filing date -
Jun 7, 1994
priority date (Note) -
Expired
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Abstract
Copper chelates serve as cytotoxic agents in conjunction with a surface membrane protein receptor internalizing agent, particularly TNF, which has independent cytotoxic activity, for use against target cells. By employing concentrations of the two agents, where the agents have substantially reduced adverse side effects, the combination is shown to have effective cytotoxic activity.
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