Method of treating HIV infection and related secondary infections with defibrotide
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United States of America Patent
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Apr 29, 1997
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app pub date -
Jan 24, 1994
filing date -
Aug 21, 1991
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Abstract
Oligonucleotides, polynucleotides and derivatives thereof, such as defibrotide, are agents of genetic modulation at the levels of transcription, translation, secondary messengers and cellular signal transduction systems. Such agents can be used to treat HIV infection. Preferably, treatment involves modifying the dose of such agents in response to observed fluctuations (e.g., increase, decrease, appearance, disappearance) in normal, disease and repair markers.
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