Spherical granule, production method thereof and medicinal preparation using said granule
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United States of America Patent
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Apr 8, 1997
Issued Date -
N/A
app pub date -
Oct 17, 1995
filing date -
Jan 12, 1993
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Abstract
The spherical granules useful as a precipient for medicines and foods, and a production method thereof. A spherical granule comprises 95% by weight or more of lactose, and has a long diameter/short diameter ratio of 1.2 or less, and, when aggregated, a bulk density of 0.7 g/ml or more and an angle of repose of 35.degree. or less. The spherical granule is produced by feeding lactose particles into a granulating and coating apparatus equipped with a horizontal rotary disk having a smooth surface to contact with the granules, and by spraying lactose solution while the above-mentioned rotary disk is rotated.
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