Osteoinduction substance, method of manufacturing the same, and bone filling material including the same
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United States of America Patent
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Apr 8, 1997
Grant Date -
N/A
app pub date -
Jul 22, 1996
filing date -
Jul 20, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An osteoinduction substance is extracted from animal bones and essentially comprises Mg, Si, Ca, and Na. The osteoinduction substance is manufactured by subjecting the animal bone to acid dipping, liming, neutralization, thermal extraction, condensation, and dehydration to obtain gelatin. The gelatin is then subjected to deproteinization under a nonheat or a low-temperature condition to extract the osteoinduction substance. The osteoinduction substance is mixed with at least one of hydroxyapatite powder and chitosan to form a bone filling material. When the osteoinduction substance is mixed with chitosan sol, a bone filling material of a sheet type is obtained.
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