Process for producing 7.beta.-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme
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United States of America Patent
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Mar 18, 1997
Grant Date -
N/A
app pub date -
Dec 30, 1994
filing date -
Jan 14, 1994
priority date (Note) -
Expired
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Abstract
The present invention relates to a process for producing large amounts of 7.beta.-(4-carboxybutanamido)-cephalosporanic acid acylase ('GA') enzyme, which process consists in growing, under suitable culture conditions, a recombinant Escherichia coli K12 strain and subsequently extracting the enzyme from the resulting culture. Enzyme production is controlled by a particular expression system which can be induced by corn-steep liquor, an extremely low cost component of the culture medium. The enzyme can be used in the enzymatic preparation of 7-amino-cephalosporanic acid by starting from 7.beta.-(4-carboxybutanamido)-cephalosporanic acid.
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