Preparation of phosphoramidon
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United States of America Patent
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Mar 4, 1997
Issued Date -
N/A
app pub date -
Jul 3, 1995
filing date -
Jun 30, 1993
priority date (Note) -
Expired
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Abstract
Compound of formula (I): ##STR1## in which: R.sub.1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group, R.sub.2 represents an unsubstituted or substituted alkyl group, X.sub.1 represents --NH--, X.sub.2 represents --O--, R.sub.3 represents a hydrogen atom or an alkyl or phenyl group, R.sub.4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different, R.sub.5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as endothelin convertase inhibitor.
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