N-oxides and derivatives of chlorambucil for treating hypoxic tumor cells
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United States of America Patent
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Feb 11, 1997
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app pub date -
Oct 20, 1994
filing date -
Oct 20, 1994
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Abstract
This invention relates to compounds which are N-oxides and derivatives of chlorambucil and which, under certain conditions, (1) are stable in hypoxic and oxic cells, (2) are toxic in cells having varying degrees of hypoxia, and (3) show little toxicity to oxic cells. These compounds have the general formula set out below and are used to treat tumorous cells: ##STR1## wherein R is an alkyl, aryl, or derivatives thereof, such as CH.sub.3 OCH.sub.2 CH.sub.2 --; CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 CH.sub.2 --; CH.sub.3 (CH.sub.2).sub.3 OCH.sub.2 CH.sub.2 Cl; or any one of the following: ##STR2##
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