Backbone modified oligonucleotide analogs

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United States of America Patent

PATENT NO 5602240
SERIAL NO

08140206

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Abstract

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Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --NR--C(O)--R--CH.sub.2, and CH.sub.2 --C(S)--NR--CH.sub.2. Methods for preparing and using these oligonucleotide analogs are also provided.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGBASEL SUI BASEL BASEL-STADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cook, Phillip D Carlsbad, CA 44 9277
De, Mesmaeker Alain Kaenerkinden, CH 42 1436
Lebreton, Jacques Marseilles, FR 12 932
Waldner, Adrian Allschwil, CH 17 987

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