Immunoactive peptides and antibodies and their use in anti-allergy treatment
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United States of America Patent
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Feb 11, 1997
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N/A
app pub date -
Jun 7, 1995
filing date -
Jun 15, 1989
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Abstract
An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide while inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula: Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, SEQ ID NO: 6 optionally amidated at the C terminal. Antibodies to the histamine-releasing peptide are useful for passive immunization.
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