Aldehydic agents for allosteric modification of hemoglobin
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United States of America Patent
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Feb 4, 1997
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N/A
app pub date -
Sep 19, 1994
filing date -
Sep 19, 1994
priority date (Note) -
Expired
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Abstract
Chemical compounds which interact inside the central water cavity of hemoglobin and bridge between the two .alpha. subunits can be used to allosterically modify hemoglobin towards tense and relaxed states. The functional groups employed are aldehydes and carboxylic acids, wherein the aldehydes form covalent bonds (schiff base) with amino acid residues of hemoglobin and the carboxylic acids form ionic bonds with amino acid residues of hemoglobin. Particularly useful compounds within the practice of this invention bond to the n-terminal valine of one .alpha. subunit of hemoglobin, and the lysine 99 and/or arginine 141 of the other .alpha. subunit.
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