Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia
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United States of America Patent
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Dec 17, 1996
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app pub date -
Aug 13, 1993
filing date -
Feb 10, 1993
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Abstract
This invention relates to a method of preventing hyperalgesia and other undesirable side-effects associated with the administration of growth factor, including nerve growth factor, utilizing an antagonist capable of inactivating excitatory opioid receptor-mediated functions on neurons in the nociceptive pathway. In addition, this invention relates to a composition comprising a growth factor and an antagonist capable of inactivating excitatory opioid receptor-mediated functions on neurons in the nociceptive pathway.
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