Treatment of infertile sperm in vitro with thymosin .alpha..sub.1 to enhance penetration of mammalian ova
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United States of America Patent
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Dec 17, 1996
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app pub date -
Apr 15, 1994
filing date -
Nov 17, 1992
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Abstract
The present invention relates to a method for increasing penetration of mammalian ova by mammalian male sperm by contacting sperm in vitro with a penetration-enhancing amount of a penetration-enhancing thymosin polypeptide or a penetration enhancing anti-thymosin antibody. In preferred embodiments, treatment comprises contacting mammalian sperm with thymosin .alpha..sub.1 or antibodies to thymosin .alpha..sub.1 or thymosin .beta..sub.4.
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