1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8a.beta.)-6-isoquinolineamine derivatives, preparation method therefor and therapeutical use thereof
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United States of America Patent
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Dec 3, 1996
Grant Date -
N/A
app pub date -
Apr 27, 1995
filing date -
Oct 28, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8a.beta.)-isoquinolineamines of formula (I), wherein groups R.sup.1 -R.sup.3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.
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