DNA encoding granulocyte colony-stimulating factor receptor and protein thereof
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United States of America Patent
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Nov 12, 1996
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Sep 22, 1992
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Mar 23, 1990
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Abstract
A murine G-CSF receptor cDNA was cloned from a cDNA library prepared from mouse myeloid leukemia cells and the structure analyzed. A human G-CSF receptor cDNA was then cloned from cDNA libraries constructed from human placenta cells or human histocytic lymphoma cells using the murine G-CSF receptor cDNA as a probe, the structure analyzed and expressed in a host cell transformed with it. The stable production of human G-CSF receptor can be accomplished by transforming a host cell with the cloned G-CSF receptor cDNA and making the transformant express the G-CSF receptor.
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