Process for preparing cephalosporin compounds from reactive organic acid derivatives
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Oct 22, 1996
Grant Date -
N/A
app pub date -
Jun 10, 1994
filing date -
Jun 10, 1993
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention provides a process for preparing cephem derivatives having the following general formula (I): ##STR1## in which R.sup.1 represents a carboxy group or a protected carboxy group which can form the salt of --COO.sup.- M.sup.+ with an alkali metal ion (M.sup.+) such as sodium, or may represent --COO.sup.- when R.sup.2 has a substituent having positive electric charge such as pyridinium, pyrimidinium or thiazolium, R.sup.2 represents hydrogen, acyloxymethyl, heterocyclic methyl or heterocyclic thiomethyl, each of which can be substituted with appropriate substituents, R.sup.3 represents hydrogen or an amino-protecting group, R.sup.4 represents C.sub.1 -C.sub.4 alkyl or phenyl, or together with the oxygen or phosphorus atom to which it is attached may form a 5- or 6-membered heterocyclic ring, and Q represents N or CH, characterized in that a reactive thiophosphate derivative of thia(dia)zole acetic acid having the following general formula (II): ##STR2## wherein R.sup.3, R.sup.4 and Q are defined as above is acylated with an 7-ACA derivative having the following general formula (III): ##STR3## wherein R.sup.1 and R.sup.2 are defined as above, in the presence of a solvent and a base.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully