Bioreactor for culturing and propagating cells with a woven motionless mixing element

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United States of America Patent

PATENT NO 5565361
SERIAL NO

08455843

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Abstract

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A bioreactor, motionless mixing element with attached cells, and method for the enhanced cultivation and propagation of cells in a bioreactor method, and which bioreactor comprises a housing and contains within the housing a motionless mixing element, the attachment of cells to the mixing element and a nutrient composition permitting the cell growth and division of the attached cells, and which motionless mixing element and the method and bioreactor comprise a porous, fibrous sheet material; for example, of a corrugated or knitted, woven wire material, such as stainless steel or titanium, and of selected dimensions as to the fiber diameter and height, to provide a maximum surface area for the attachment of the cells to be cultivated, with the ratio of the fibrous, geometric surface area of the porous, fibrous sheet material to that of a sheet material of the same shape being greater than about 1.0; for example, 1.5, and typically, for example, having a surface area for cell growth of about 2000 to 3000 M.sup.2 /M.sup.3.

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Patent Owner(s)

Patent OwnerAddress
SULZER CHEMTECHHAGIFELDSTRASSE 10 WINTERTHUR CH-8404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mutsakis, Michael Brooklyn, NY 5 62
Porcelli, Joseph P Lyndhurst, NJ 2 16

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