Cyclic bradykinin antagonist peptides
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United States of America Patent
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Aug 6, 1996
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Jul 25, 1994
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Feb 17, 1993
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Abstract
Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the peptide through covalent bonding of the amino acid side chains. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
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