Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
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United States of America Patent
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Jul 30, 1996
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app pub date -
Jul 28, 1994
filing date -
Oct 8, 1992
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Abstract
Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at at positions 2 through 5 are replaced by olefinic aminoalkenoyl groups to reduce the peptide nature of the compounds. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
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