2-substituted quinolines for the treatment of leishmaniasis

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United States of America Patent

PATENT NO 5541196
SERIAL NO

08211239

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Abstract

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Substituted quinolines having formula (1), wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 each independently represent a hydrogen atom, a linear or branched C.sub.1-7 alkyl, alkenyl, epoxy-alkyl or mono/polyalcohol group; an amine group or an amide group, an OR group in which R is hydrogen or a C.sub.1-7 alkyl or alkenyl group or a phenyl group; and R.sub.2 is an OR group in which R is as defined above, or a C.sub.1-7 alkyl alkenyl or epoxyalkyl group, a phenyl, phenol, methylenedioxyphenyl, or dimethoxyphenyl group, or a C.sub.1-7 alkyl, alkenyl or epoxyalkyl group, a phenyl, phenol, methylenedioxyphenyl, or dimethoxphenyl group or a C.sub.1-7 alkyl, alkenyl or epoxy-alklyl group comprising at least one of the following substituents: a C.sub.1-4 alkyl or alkenyl group; a phenyl, phenol, dimethylphenyl, dimethoxyphenyl or methylenedioxphenyl group; or an OR group in which R is hydrogen or a C.sub.1-4 alkyl or alkenyl group; or an NHR group in which R is hydrogen or a C.sub.1-4 alkyl or alkenyl group; or an amide group; or else R.sub.2 and R.sub.3 together form a furan ring; and salts and derivatives thereof; are used as drugs, particularly anti-lieshmanials.

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Patent Owner(s)

Patent OwnerAddress
INSTITUT FRANCAIS DE RECHERCHE SCIENTIFIQUE POUR LE DEVELOPPMENT EN COOPERATION213 RUE LAFAYETTE 75480 PARIS CEDEX 10

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Angelo, Barrios Alcira La Paz, BO 1 10
Bruneton, Jean Avrille, FR 1 10
Fournet, Alain Ossages, FR 7 32
Gantier, Jean Charles Chatenay Malabry, FR 1 10
Hocquemiller, Reynald Chatenay Malabry Cedex, FR 3 22
Munoz, Victoria La Paz, BO 1 10
Richomme, Pascal Angers, FR 5 10
Roblot, Francedillaois Paris, FR 1 10

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