Process for preparing microspheres for the prolonged release of the LHRH hormone and its analogues, microspheres and formulations obtained
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United States of America Patent
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Jul 30, 1996
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N/A
app pub date -
Jul 27, 1993
filing date -
Jul 27, 1992
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Abstract
Process for preparing microspheres for the prolonged release of the LHRH hormone and of its analogues, the hormone being dispersed in a water-insoluble polymer or copolymer matrix, the solvent evaporation process is characterized by the use of a pair of organic solvents of which one makes it possible more specifically to obtain a homogeneous suspension of the hormone in the pulverulent state by simply stirring and of which the other is slightly water-miscible so as to allow more specifically the microdispersion of the organic phase in the aqueous phase in which the hardening of the microspheres is performed. This process leads to the preparation of LHRH-containing microspheres which are noteworthy for their purity, especially to microspheres with complex matrices, as well as to formulations comprising at least two types of microspheres.
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