Pyrrolopyridazines having gastrointestinal protective effects
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United States of America Patent
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Jul 9, 1996
Grant Date -
N/A
app pub date -
Apr 25, 1994
filing date -
Oct 25, 1991
priority date (Note) -
Expired
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Abstract
Compounds of formula (I) ##STR1## wherein R1 stands for alkyl or R5-substituted alkylene; R2 stands for alkyl; R3 stands for hydrogen, halogen, --CHO (formyl), hydroxymethyl, nitro, amino, or the substituent --CH.sub.2 O--COR7; R4 stands for halogen or the substituent --A--B--R6; R5 stands for furyl, thienyl, tetrahydrofuryl, phenyl or phenyl substituted by one or two identical or different substituents from the group composed of halogen, alkyl, alkoxy, nitro, --NH--CO--NH.sub.2 (ureido), amino, alkylcarbonyl-amino and alkoxycarbonylamino; R7 stands for alkyl, alkoxy-alkyl, alkoxycarbonyl-alkyl or carboxy-alkyl; A stands for O (oxygen) or NH; B stands for a bond, --CH.sub.2 -- (methylene) or --CH.sub.2 CH.sub.2 --(1,2-ethylene); and n stands for the number 0 or 1; are useful for preventing and treating gastrointestinal disorders.
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