Processing analytical reagents
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United States of America Patent
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Jul 2, 1996
Grant Date -
N/A
app pub date -
Aug 6, 1993
filing date -
Mar 9, 1991
priority date (Note) -
Expired
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Abstract
A method of preparing functionalized particles including (a) treating an activated substrate (CPG) with a bifunctional cross-linking agent containing a cleavable bond so as to immobilize the cross-linking agent, (b) conjugating an activated particle (P) with the immobilized cross-linking agent, and (c) cleaving the cleavable bond so as to separate the particle (P) from the substrate (CPG). The functionalized particles subsequently can be conjugated to biologically active molecules for use in assay methods.
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