Derivatives of human haemoglobin, method for preparing them, products derived therefrom and use of these derivatives and products

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United States of America Patent

PATENT NO 5514780
SERIAL NO

07926673

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates, as new compounds, to derivatives of tetrameric human haemoglobin corresponding to the covalent coupling of a haemoglobin tetramer and a polycarboxy-substituted compound having at least 4 -COO.sup.- groups, the said polycarboxy-substituted compound effecting an internal crosslinking of the two dimers of haemoglobin and conferring thereon an affinity for oxygen which is compatible with an in vivo use of the conjugate when the natural allosteric effector of haemoglobin is not present. Among carboxy-substituted compounds, special mention is made of benzenehexacarboxylate and benzenetetracarboxylate.

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Patent Owner(s)

Patent OwnerAddress
PASTEUR MERIEUX SERUMS ET VACCINS58 AVENUE LECLERC F-69007 LYON

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dellacherie, Edith Malzeville, FR 6 40
Grandgeorge, Michel Vaugneray, FR 6 37
Sacco, Daniel Nancy, FR 5 89

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