Process for the preparation of ribonucleotide reductase inhibitors
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United States of America Patent
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Apr 16, 1996
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app pub date -
May 11, 1995
filing date -
May 12, 1992
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Abstract
The present invention is directed toward a novel process of preparing 2'-exocyclic vinylfluoride derivatives of cytidine analogues for use as ribonucleotide reductase inhibitors. The novel process of the present invention utilizes a cytidine derivative as the required starting material and provides the ribonucleotide reductase inhibitor in a more efficient five step reaction sequence. The present invention further provides the ribonucleotide reductase inhibitor in a four step reaction sequence and results in an overall yield of greater than 35%.
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