Butyrophenone transdermal compositions
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United States of America Patent
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-
Dec 26, 1995
Grant Date -
N/A
app pub date -
Apr 21, 1994
filing date -
Apr 28, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A butyrophenone transdermal composition which comprises the following components (a) to (f): (a) a water-soluble polymer which is constituted by a monomer containing, partly or wholly, aliphatic carboxylic acid having a polymerizable double bond or a salt of the carboxylic acid, (b) a cross linking agent, (c) a cross linking promoter, (d) water, (e) a butyrophenone drug, and (f) a solvent for the butyrophenone drug (e), as essential components. The pH of the composition is adjusted to fall in the range of 5.5 to 8.0. With the composition of the invention, the concentration of the active component butyrophenone in blood can be controlled. The composition is capable of exhibiting its primary action, antiemetic action, without causing rash in the skin and with less adverse side effects.
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