S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins A, B, Y and aglycones
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United States of America Patent
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Nov 21, 1995
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N/A
app pub date -
Feb 4, 1994
filing date -
Sep 3, 1993
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Expired
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Abstract
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.
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