Ginkgolide derivatives and a process for preparing them
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United States of America Patent
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Nov 14, 1995
Grant Date -
N/A
app pub date -
Jul 5, 1994
filing date -
Sep 18, 1991
priority date (Note) -
Expired
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Abstract
The present invention relates to new ginkgolide derivatives of the formula (I) as below which represents PAF-antagonistic activity and the method for the preparation thereof, by that the cyclic compounds of substituted Ginkgolide B derivatives are produced by reacting the known Ginkgolide B and C mixture having the hydroxy group in 1- and 10-carbon with acid, then they are separated, and separated Ginkgolide B derivatives is hydrolyzed in acidic aqueous solution. And the present invention is related to make use it as PAF-antagonistic agent through separating the only one component of the new ginkgolide derivative by those methods. ##STR1##
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